PECULIARITIES OF CHANGES IN TRACE-ELEMENT COMPOSITION OF. Are neonatal brain lesions due to intrauterine infection related to mode of delivery? Mierzejewska // Biblioteka Trenera, Warszawa, 2009. Kletochnykh komponentov stromy v razvitii opukholi / N.M. Berezhnaya, V.F. Biblioteka ( Use Case Diagram (UML)) Biblioteka. By Bojan Dimic. UseCase za program Biblioteka--You can edit this template and create your own diagram. Creately diagrams can be exported and added to Word, PPT (powerpoint), Excel, Visio or any other document. Use PDF export for high quality prints and SVG export for large sharp images.
When starting up my web site for the first time, I'm getting this error Could not load type 'System.Runtime.CompilerServices.ExtensionAttribute' from assembly 'mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' What am I doing wrong? I am using.NET 4 and am starting the site from Visual Studio.
The only thing I've changed recently is add Simple Injector (via Nuget) into my project. Could not load type 'System.Runtime.CompilerServices.ExtensionAttribute' from assembly mscorlib Yes, this technically can go wrong when you execute code on.NET 4.0 instead of.NET 4.5. The attribute was moved from System.Core.dll to mscorlib.dll in.NET 4.5.
While that sounds like a rather nasty breaking change in a framework version that is supposed to be 100% compatible, a TypeForwardedTo attribute is supposed to make this difference unobservable. As Murphy would have it, every well intended change like this has at least one failure mode that nobody thought of. This appears to go wrong when ILMerge was used to merge several assemblies into one and that tool was used incorrectly. A good feedback article that describes this breakage. It links to a that describes the mistake. It is rather a long article, but if I interpret it correctly then the wrong ILMerge command line option causes this problem: /targetplatform:'v4,c: windows Microsoft.NET Framework v4.0.30319' Which is incorrect. When you install 4.5 on the machine that builds the program then the assemblies in that directory are updated from 4.0 to 4.5 and are no longer suitable to target 4.0.
Those assemblies really shouldn't be there anymore but were kept for compat reasons. The proper reference assemblies are the 4.0 reference assemblies, stored elsewhere: /targetplatform:'v4,C: Program Files (x86) Reference Assemblies Microsoft Framework.NETFramework v4.0' So possible workarounds are to fall back to 4.0 on the build machine, install.NET 4.5 on the target machine and the real fix, to rebuild the project from the provided source code, fixing the ILMerge command. Do note that this failure mode isn't exclusive to ILMerge, it is just a very common case. Any other scenario where these 4.5 assemblies are used as reference assemblies in a project that targets 4.0 is liable to fail the same way.
Judging from other questions, another common failure mode is in build servers that were setup without using a valid VS license. And overlooking that the multi-targeting packs are a.
Using the reference assemblies in the c: program files (x86) subdirectory is a rock hard requirement. Starting at.NET 4.0, already important to avoid accidentally taking a dependency on a class or method that was added in the 4.01, 4.02 and 4.03 releases.
But absolutely essential now that 4.5 is released. I had this problem, except the type it couldn't load was System.Reflection.AssemblyMetadataAttribute.
The web application was built on a machine with.NET 4.5 installed (runs fine there), with 4.0 as the target framework, but the error presented itself when it was run on a web server with only 4.0 installed. I then tried it on a web server with 4.5 installed and there was no error. So, as others have said, this is all due to the screwy way Microsoft released 4.5, which basically is an upgrade to (and overwrite of) version 4.0. The System.Reflection assembly references a type that doesn't exist in 4.0 (AssemblyMetadataAttribute) so it will fail if you don't have the new System.Reflection.dll. You can either install.NET 4.5 on the target web server, or build the application on a machine that does not have 4.5 installed.
Far from an ideal resolution. I had this exact same problem with a site (Kentico CMS), starting development in 4.5, finding out the production server only supports 4.0, tried going back down to target framework of 4.0. Compiling the other posts in this thread (specifically changing target framework to.Net 4 and.Net 4.5 still being referenced). I searched through my solution and found that a handful of the NuGet packages were still using libraries with targetFramework='net45'.
Packages.config (before): I changed the projects target framework back to 4.5, removed all NuGet libraries, went back down to 4.0 and re-added the libraries (had to use some previous versions that were not dependent on 4.5). Packages.config (after). Advance warning for you, EVEN IF you resolve the issue otherwise, your obfuscated version will be broken again, so you may never know you resolved it.
![Biblioteka Biblioteka](http://konspekta.net/bazaimgstudall/1363754075547.files/image135.png)
That is, you CAN build on 4.5 and deploy without trouble to 4.0-only machines. All that was necessary for me was the multi-targeting patch Hans Passant mentions. I could see from looking at the manifest in ILDASM that it was correctly targeting System.Core instead of mscorlib. But NOT on the version that had been run through SmartAssembly (v5.5).
– Jan 23 '15 at 21:06. We ran into this problem and tracked it down to the package that we were using to help with our Google Maps views (Geocoding.net version 3.1.0 published 2/4/2014). The Geocoding dll appears to be.Net 4.0 when you examine the package file or view it using Jet Brains’ Dot Peek application; however, a colleague of mine says that it was compiled using ilmerge so it is most likely related to the ilmerge problems listed above. It was a long process to track it down. We fetched different changesets from TFS till we narrowed it down to the changeset that added the aforementioned NuGet package. After removing it, we were able to deploy to our.NET 4 server.
. Beisenova, A.; Boos, E.; Haungs, A.; Sadykov, T.; Salihov, N.; Shepetov, A.; Tautayev, Y.; Vildanova, L.; Zhukov, V. 2017-06-01 The complex EAS installation of the Tien Shan mountain cosmic ray station which is situated at a height of 3340 m above sea level includes the scintillation and Cherenkov detectors of charged shower particles, an ionization calorimeter and a set of neutron detectors for registering the hadronic component of the shower, and a number of underground detectors of the penetrative EAS component.
Now it is intended to expand this installation with a promising method for detecting the radio-emission generated by the particles of the developing shower. The facility for radio-emission detection consists of a three crossed dipole antennae, one being set vertically, and another two - mutually perpendicularly in a horizontal plane, all of them being connected to a three-channel radio-frequency amplifier of German production. By the passage of an extensive air shower, which is defined by a scintillation shower detector system, the output signal of antenna amplifier is digitized by a fast multichannel DT5720 ADC of Italian production, and kept within computer memory. The further analysis of the detected signal anticipates its operation according to a special algorithm and a search for the pulse of radio-emission from the shower.
A functional test of the radio-installation is made with artificial signals which imitate those of the shower, and with the use of a N1996A type wave analyzer of Agilent Technologies production. We present preliminary results on the registration of extensive air shower emission at the Tien Shan installation which were collected during test measurements held in Summer 2016. Li JY 2016-04-01 Full Text Available Jingya Li,1,. Ruizhen Zhao,1,. Xiaoli Li,1 Wenjun Sun,1 Miao Qu,1 Qisheng Tang,1 Xinke Yang,1 Shujing Zhang2 1Third Affiliated Hospital, 2School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China.These authors contributed equally to this work Background: Shen-Qi-Jie- Yu-Fang (SJF is composed of eight Chinese medicinal herbs. It is widely used in traditional Chinese medicine for treating postpartum depression (PPD.
Previous studies have shown that SJF treats PPD through the neuroendocrine mechanism. Aim: To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg cells. Materials and methods: Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal.
After hormone withdrawal, the PPD rats were treated with SJF or fluoxetine for 1, 2, and 4 weeks. Levels of Treg cells in peripheral blood were measured by flow cytometry analysis.
Serum interleukin (IL-1β and IL-6 were evaluated by enzyme-linked immunosorbent assay, and gene and protein expressions of IL-1RI, IL-6Rα, and gp130 in the hippocampus were observed by reverse-transcription polymerase chain reaction and Western blot. Results: Serum IL-1β in PPD rats increased at 2 weeks and declined from then on, while serum IL-6 increased at 1, 2, and 4 weeks.
Both IL-1β and IL-6 were downregulated by SJF and fluoxetine. Changes in gene and protein expressions of IL-1RI and gp130 in PPD rats were consistent with changes in serum IL-1β, and were able to be regulated by SJF and fluoxetine. The levels of Treg cells were negatively correlated with serum IL-1β and IL-6, and were decreased in PPD rats. The levels of Treg cells were increased by SJF and fluoxetine. Conclusion: Dysfunction of proinflammatory cytokines and Tregs in different stages of PPD was attenuated by SJF and fluoxetine through. Zhang, Keda; Zeng, Xiaobin; Chen, Yonggang; Zhao, Rong; Wang, Hui; Wu, Jinhu 2017-01-25 Qian- Yu decoction (QYD) is a traditional Chinese medicinal recipe composed of Radix astragali (Astragalus membranaceus (Fisch.) Bunge var. Mongholicus (Bunge) P.K.
Hsiao, Fabaceae ), Herba epimedii (Epimedium brevicornum Maxim., Berberidaceae), Herba leonuri (Leonurus japonicus Houtt., Lamiaceae), Cortex phellodendri (Phellodendron chinense Schneid., Rutaceae) and Radix achyranthis bidentatae (Achyranthes bidentata Bl., Amaranthaceae). This study aimed to evaluate the therapeutic activity of QYD against carrageenan-induced chronic prostatic/chronic pelvic pain syndrome (CP/CPPS) in rats and further elucidate its effective components. Three types of components, total polysaccharides, total flavonoids and total saponins were separately extracted from QYD.
Carrageenan-induced CP/CPPS rats were intragastrically administered with lyophilized product of QYD, individual extracts and all the combined forms of extracts for three weeks. Prostatic index (PI) was determined and histopathological analysis was performed. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), cyclooxygenase-2 (COX-2) and prostaglandin E2 (PEG2) in rat prostate tissues were measured using ELISA. The production of inducible nitric oxide synthase (iNOS) was evaluated by an enzymatic activity assay, and the release of nitric oxide (NO) was determined by a nitrate/nitrite assay.
Treatment with QYD significantly ameliorated the histological changes of CP/CPPS rats and reduced the PI by 44.3%, with a marked downregulation of TNF-α (42.8% reduction), IL-1β (45.3%), COX-2 (36.6%), PGE2 (44.2%), iNOS (54.1%) and NO (46.0%). Each of three extracts attenuated the symptom of CP/CPPS, but much more weakly than QYD. The combined administration of three extracts showed efficacy comparable to that of QYD while better than that of any combination of two extracts. A principal component analysis of the six inflammatory mediators as variables indicated that the effects of TS on CP. Luo, Qiulan; Zhang, Claire Shuiqing; Yang, Lihong; Zhang, Anthony Lin; Guo, Xinfeng; Xue, Charlie Changli; Lu, Chuanjian 2017-11-06 Chinese herbal medicine formula Yu ping feng san (YPFS) is commonly used for allergic rhinitis (AR). Previous review had summarized the effectiveness and safety of YPFS, however without any subgroup analysis performed to provide detailed evidence for guiding clinical practice. YPFS was recommended for the management of AR by Chinese medicine clinical practice guideline, but the treatment duration of YPFS was also not specified.
The aim of this study is to evaluate the effectiveness and safety of YPFS in treating adult AR with the most recent evidence, and attempt to specify the duration of utilisation through subgroup meta-analyses. Seven databases were searched from their inceptions to September 2017. Randomized controlled trials (RCTs) evaluating YPFS for adult AR were included. Methodological quality of studies was assessed using the Cochrane risk of bias tool. Meta-analysis and subgroup meta-analyses were conducted for evaluating the effectiveness of YPFS. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used for rating the quality of evidence. Twenty-two RCTs involving 23 comparisons were included in this review.
YPFS was compared to placebo, pharmacotherapy, and used as an add-on treatment compared to pharmacotherapy. Meta-analyses were feasible for the outcomes of four individual nasal symptom scores and 'effective rate'. Four individual nasal symptom scores decreased after YPFS' combination treatment: itchy nose (MD-0.46, 95% CI-0.50, -0.42), sneezing (MD-0.41, 95% CI-0.47, -0.35), blocked nose (MD-0.46, 95% CI-0.54, -0.39) and runny nose (MD-0.42, 95% CI-0.58, -0.26). Based on 'effective rate', meta-analysis showed that YPFS did not achieve better effect than pharmacotherapy (RR1.07, 95%CI 0.94, 1.22), but its combination with pharmacotherapy seemed more effective than pharmacotherapy alone (RR1.27, 95%CI 1.19, 1.34) (low quality). Subgroup analysis suggested that YPFS was not superior to the second.
Chen, Qi; Lei, Lei; Li, Yan; Wang, Ji-Guang 2017-10-01 The present study aimed to evaluate the accuracy of the automated oscillometric upper-arm blood pressure monitor YuWell YE690A for blood pressure measurement according to the International Protocol of the European Society of Hypertension revision 2010. Systolic and diastolic blood pressures were measured sequentially in 33 adult Chinese (12 women, 44.2 years of mean age) using a mercury sphygmomanometer (two observers) and the YE690A device (one supervisor). A total of 99 pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases. All the blood pressure requirements were fulfilled. The YuWell YE690A device achieved the targets in part 1 of the validation study. The number of absolute differences between device and observers within 5, 10, and 15 mmHg was 79/99, 96/99, and 97/99, respectively, for systolic blood pressure and 72/99, 95/99, and 98/99, respectively, for diastolic blood pressure.
The device also fulfilled the criteria in part 2 of the validation study. Thirty-one and 25 participants for systolic and diastolic blood pressure, respectively, had at least two of the three device-observer differences within 5 mmHg (required ≥24). No participant for systolic and two participants for diastolic blood pressure had all the three device-observer comparisons greater than 5 mmHg. The YuWell blood pressure monitor YE690A has passed the requirements of the International Protocol revision 2010 and hence can be recommended for blood pressure measurement in adults. Yi Zheng 2007-01-01 Full Text Available The essay explores the public social dimension of the “great cultural essays” as a popular post-socialist genre. It looks into the genre’s emergence and popularity as part of the making of a middleclass taste in contemporary China and its claim to a re-imagined cultural national inheritance. In particular, the discussion focuses on the example of essayist Yu Qiuyu and examines the implications of his successful transformation of an obsolete historical “Culture” into a desirable commodity that offers spiritual home to the aspiring and successful of a “Greater China”.
Nefedov 2016-01-01 This book is a study at the intersection of such academic disciplines as general history, history of state and law and source study. The subcect of R. Pochevalev’s book appears very relevant since the interest of the scientific community and readership toward the Golden Horde and its role in the history of the Russian state remains traditionally high for several centuries. However, the author is trying to take a fresh look at this state and refute the stereotype of the Golden Horde as a. Cherepashchuk, Anatolii M 2009-01-01 We comment on the methodological note by A A Grib and Yu V Pavlov Phys.
52 257 (2009) to show that its authors are incorrect in understanding a passage that they quote from A M Cherepashchuk's book Black Holes in the Universe (Fryazino: Vek-2, 2005, p.7) and which supposes an astronaut to be at rest in the vicinity of the horizon (not to fall freely into a black hole!). With this error corrected, Grib and Pavlov's note is quite useful methodologically.
(letters to the editors). Chih-Jung Yao 2012-01-01 Full Text Available There are increasing pieces of evidence suggesting that the recurrence of cancer may result from a small subpopulation of cancer stem cells, which are resistant to the conventional chemotherapy and radiotherapy. We investigated the effects of Chinese herbal mixture Tien-Hsien Liquid (THL on the cancer stem-like side population (SP cells isolated from human hepatoma cells. After sorting and subsequent culture, the SP cells from Huh7 hepatoma cells appear to have higher clonogenicity and mRNA expressions of stemness genes such as SMO, ABCG2, CD133, β-catenin, and Oct-4 than those of non-SP cells.
At dose of 2 mg/mL, THL reduced the proportion of SP cells in HepG2, Hep3B, and Huh7 cells from 1.33% to 0.49%, 1.55% to 0.43%, and 1.69% to 0.27%, respectively. The viability and colony formation of Huh7 SP cells were effectively suppressed by THL dose-dependently, accompanied with the inhibition of stemness genes, e.g., ABCG2, CD133, and SMO. The tumorigenicity of THL-treated Huh7 SP cells in NOD/SCID mice was also diminished. Moreover, combination with THL could synergize the effect of doxorubicin against Huh7 SP cells. Our data indicate that THL may act as a cancer stem cell targeting therapeutics and be regarded as complementary and integrative medicine in the treatment of hepatoma. Hu, X.; Ni, B.; Zheng, P.; Li, M. 2018-01-01 The simple sequence repeat markers were used to investigate the population genetic diversity and structure of 212 germplasm samples from 14 apricot (Prunus armeniaca) populations in the western of Tien-Shan Mountains, Sinkiang, China.
The relatively high expected heterozygosity and Shannon's diversity index indicated the apricot populations maintained a high level of genetic diversity (He = 0.6109, I = 1.2208), with the population in Tuergen ditch of Xinyuan County having the highest genetic diversity index. A high level of intra-population genetic differentiation (91.51%) and a lower level of inter-population genetic differentiation were occurred, as well as a moderate but steady inter-population gene flow (Nm = 2.3735). The self-incompatible pattern, wide distribution, and long-distance pollen transmission via insects and gale are the main factors underlying the genetic variation structure.
The UPGMA cluster analysis and genetic structure analysis showed that apricot germplasm could be divided into two or four groups, which was basically consistent with the geographic distribution pattern. The inter-population genetic distance and geographic distance showed a significant correlation (r = 0.2658, p.